In 2003, Angel co-starred with Richard Gutierrez in the fantaserye "Mulawin" where she portrayed the character of Alwina. After "Mulawin", Angel Locsin was given her first major role in the remake of super heroin "Darna" of Mars Ravelo. Darna made waves in local TV. It is the first primetime program to reach a rating of 47.1% and recorded the highest rating by a GMA show for that year (2005) when it reached 52.1% in its fourth episode.
"Darna" put Angel to prominence. Due to the show's popularity, Angel wsa offered several Tv-Shows, movies, endorsements and big projects which catapulted Angel to where she is now.
After "Darna", Angel starred in two more Kapuso primetime shows namely "Majika" with Dennis Trillo and "Asian Treasures" with Robin Padilla. "Asian Treasures" is the last project of Angel in GMA-7 as she then transferred to ABS-CBN.